PREMUROSA
Precision medicine for musculoskeletal regeneration, prosthetics, and active ageing
Marie Skłodowska-Curie Actions Innovative Training Network
Funded by the European Union
This project has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No 860462.
PREMUROSA
Starting date: 01.01.2020
End date: 31.12.2023
Duration: 48 months
TYPE OF PROJECT
Understand interactions
To gain a deep scientific understanding of the role and interactions among materials, extracellular matrix, cells and tissues in musculoskeletal regeneration, taking into account patient morbidity, comorbidity, immunological status and age.
Develop substantially new in-vitro assays
To develop substantially new in-vitro assays to test medical devices under conditions closer to clinical reality than those currently available, and to forecast personalized clinical healing and regeneration response;
New in-silico models
To develop new in-silico models and DSS to test medical devices under conditions closer to clinical reality
Generate a biological integrated-multi-OMIC signature
To generate a biological integrated-multi-OMIC signature to predict healing and regeneration responses
RESEARCH AREA
Premurosa project aims to combine the personalized clinical approach with individual ‘omic’ characterization and proper choice of medical device. The concept is “To take care with care”. This is the meaning of the Italian word “premurosa” and the ultimate goal of the ITN PREMUROSA project, aimed to train a new generation of scientists with an integrated vision of the whole value chain in musculoskeletal regeneration technologies and able to boost the necessary innovations to achieve precision principles in developing innovative devices and optimized clinical applications.
This aim will be achieved by a “triple i” (interdisciplinary, intersectoral, international) approach of thirteen ESRs, who will benefit from an excellent scientific environment, up-date technologies and supervision by international leaders in the field. They will learn to integrate academic and industrial aspects and they will sharpen their experimental and complementary skills in a well-designed and diversified and unprecedented training program.
HOW WE ARE DOING IT
Research
Musculoskeletal diseases are a major burden on individuals, healthcare and welfare systems. Treatment of musculoskeletal disorders is currently based either on prosthetic or regenerative surgical procedures, often involving medical device implantation. In both cases, individual tissue healing and regeneration, together with the appropriateness of the implanted device, markedly affect the outcome. A great improvement could be achieved by precision medicine, specifically designed on patient’s individual characteristics.
RELATED PUBLICATIONS
- www.zenodo.org
- Abreu, H., Canciani, E., Raineri, D., Cappellano, G., Rimondini, L., & Chiocchetti, A. (2022).
Extracellular Vesicles in Musculoskeletal Regeneration: Modulating the Therapy of the Future.
Cells, 11(1), 43. IF 7,666; Q2 - Cappellano, G., Abreu, H., Casale, C., Dianzani, U., & Chiocchetti, A. (2021).
Nano-microparticle platforms in developing next-generation vaccines.
Vaccines, 9(6), 606. IF:7.76; Q1
OUR PARTNERS
- Università degli Studi del Piemonte Orientale Amedeo Avogadro (UPO) – Novara, ITALY
- Aalto Korkeakoulusaatio SR (AALTO) – Espoo, FINLAND
- Ao-Forschungsinstitut Davos (ARO) – Davos, SWITZERLAND
- Rigas Tehniska Universitate (RTU) – Riga, LATVIA
- Faculty Of Technology And Metallurgy University Of Belgrade (UoB) – Belgrade, SERBIA
- Istituto Nacional De Engenharia Biomedica (INEB) – Porto, PORTUGAL
- Politecnico di Torino (POLITO) – Turin, ITALY
- Engisoft S.P.A. (ES) – Padova, ITALY
- Tampereen Korkeakoulusaatio SR (TAU) – Tampere, FINLAND
- National University of Ireland Galway (NUI) – Galway, IRELAND
- Trustech SRL (TRS) – Turin, ITALY
USEFUL LINKS
Projects
Team
Cookie policy
Privacy Policy
CONTACTS
CAAD | Corso Trieste 15/A
Novara – 28100, Italy
PREMUROSA
Precision medicine for musculoskeletal regeneration, prosthetics, and active ageing
Marie Skłodowska-Curie Actions Innovative Training Network
Funded by the European Union
This project has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No 860462.
PREMUROSA
Starting date: 01.01.2020
End date: 31.12.2023
Duration: 48 months
TYPE OF PROJECT
Understand interactions
To gain a deep scientific understanding of the role and interactions among materials, extracellular matrix, cells and tissues in musculoskeletal regeneration, taking into account patient morbidity, comorbidity, immunological status and age.
Develop substantially new in-vitro assays
To develop substantially new in-vitro assays to test medical devices under conditions closer to clinical reality than those currently available, and to forecast personalized clinical healing and regeneration response;
New in-silico models
To develop new in-silico models and DSS to test medical devices under conditions closer to clinical reality
Generate a biological integrated-multi-OMIC signature
To generate a biological integrated-multi-OMIC signature to predict healing and regeneration responses
RESEARCH AREA
Premurosa project aims to combine the personalized clinical approach with individual ‘omic’ characterization and proper choice of medical device. The concept is “To take care with care”. This is the meaning of the Italian word “premurosa” and the ultimate goal of the ITN PREMUROSA project, aimed to train a new generation of scientists with an integrated vision of the whole value chain in musculoskeletal regeneration technologies and able to boost the necessary innovations to achieve precision principles in developing innovative devices and optimized clinical applications.
This aim will be achieved by a “triple i” (interdisciplinary, intersectoral, international) approach of thirteen ESRs, who will benefit from an excellent scientific environment, up-date technologies and supervision by international leaders in the field. They will learn to integrate academic and industrial aspects and they will sharpen their experimental and complementary skills in a well-designed and diversified and unprecedented training program.
HOW WE ARE DOING IT
Research
Musculoskeletal diseases are a major burden on individuals, healthcare and welfare systems. Treatment of musculoskeletal disorders is currently based either on prosthetic or regenerative surgical procedures, often involving medical device implantation. In both cases, individual tissue healing and regeneration, together with the appropriateness of the implanted device, markedly affect the outcome. A great improvement could be achieved by precision medicine, specifically designed on patient’s individual characteristics.
RELATED PUBLICATIONS
- www.zenodo.org
- Abreu, H., Canciani, E., Raineri, D., Cappellano, G., Rimondini, L., & Chiocchetti, A. (2022).
Extracellular Vesicles in Musculoskeletal Regeneration: Modulating the Therapy of the Future.
Cells, 11(1), 43. IF 7,666; Q2 - Cappellano, G., Abreu, H., Casale, C., Dianzani, U., & Chiocchetti, A. (2021).
Nano-microparticle platforms in developing next-generation vaccines.
Vaccines, 9(6), 606. IF:7.76; Q1
OUR PARTNERS
- Università degli Studi del Piemonte Orientale Amedeo Avogadro (UPO) – Novara, ITALY
- Aalto Korkeakoulusaatio SR (AALTO) – Espoo, FINLAND
- Ao-Forschungsinstitut Davos (ARO) – Davos, SWITZERLAND
- Rigas Tehniska Universitate (RTU) – Riga, LATVIA
- Faculty Of Technology And Metallurgy University Of Belgrade (UoB) – Belgrade, SERBIA
- Istituto Nacional De Engenharia Biomedica (INEB) – Porto, PORTUGAL
- Politecnico di Torino (POLITO) – Turin, ITALY
- Engisoft S.P.A. (ES) – Padova, ITALY
- Tampereen Korkeakoulusaatio SR (TAU) – Tampere, FINLAND
- National University of Ireland Galway (NUI) – Galway, IRELAND
- Trustech SRL (TRS) – Turin, ITALY
USEFUL LINKS
Projects
Team
Cookie policy
Privacy Policy
CONTACTS
CAAD | Corso Trieste 15/A
Novara – 28100, Italy