MINDFUL
Microvesicles: INtersection between autoimmune Diseases, Food and Unhealthy Lifestyles
Funded by MIUR (Ministry of Education, University and Research)
MINDFUL
Start date: November 2018
End date: November 2022
48 months
TYPE OF PROJECT
Investigate
Investigate how diet impacts AD development and its relation with socio-economic variables
Design cytofluorimetric panel
Design a cytofluorimetric panel to sort and deeply characterize EVs in AD patients, in order to identify biomarkers and new therapeutic targets
Investigate plant and bacteria
Investigate the role played by plant and bacteria EVs in immune modulation.
RESEARCH AREA
MINDFUL project aims to investigate the relationship between the human gut microbiota and the onset of autoimmune diseases (ADs), by evaluating the contribution of different eating habits and lifestyles in dysbiosis and unravelling the extracellular vesicles (EVs)-mediated communication mechanisms between gut bacteria and immune cells.
HOW WE ARE DOING IT
Research
Autoimmune diseases (AD) like multiple sclerosis (MS), rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), and type 1 diabetes (T1D) result from an overactive immune system and show an increasing trend, possibly linked to the prevalence of the Western diet (WD) compared to the Mediterranean diet (MD). Understanding the complex interplay between lifestyle, work history, dietary patterns, and social/family networks is crucial for promoting a ‘food for health’ approach that benefits public health and the environment.
Know-how
The project was guided by scientific “cross-cultural contamination” and “complementary expertise” principles to develop innovation and to foster innovation and technological capacity. Indeed, MINDFUL was designed with long perspectives, considering the possibility to access at synergic external technological and financial resources including grants from public and private agencies and from companies.
Since the project aims to study and understand the sociological, anthropological, environmental and biological factors influencing the development and evolution of AD, it was structured in multiple units: basic researcher unit, clinical unit, microbiome unit and industry unit.
RELATED PUBLICATIONS
- Barbero Mazzucca C, Cappellano G, Chiocchetti A.
Nutrition, immunity and aging: current scenario and future perspectives in neurodegenerative diseases. CNS Neurol Disord Drug Targets.
2023 May 2. doi: 10.2174/1871527322666230502123255.Epub ahead of print.
PMID: 37138438. - Publication of a popular science article on the scientific dissemination journal “Salute33”, edition of February 2023, entitled “Malattie autoimmune e dieta: prevenire è meglio che curare”.
- Mazzucca C.B., Scotti L., Cappellano G., Barone-Adesi F., Chiocchetti A.
Nutrition and rheumatoid arthritis onset: a prospective analysis using the UK biobank.
Nutrients. 2022 Apr 8;14(8): 1554.doi:10.3390/nu14081554 - Mazzucca CB, Raineri D, Cappellano G, Chiocchetti A.
How to Tackle the Relationship between Autoimmune Diseases and Diet: Well Begun Is Half-Done.
Nutrients. 2021;13(11):3956.doi:10.3390/nu13113956
OUR PARTNERS
- Becton Dickinson Italia S.p.a. – Milan, ITALY
- Proge Farm S.r.l – Novara, ITALY
- Istituto Auxologico Italiano – Milan area, ITALY
- Università degli Studi del Piemonte Orientale Amedeo Avogadro (UPO) – Novara, ITALY
USEFUL LINKS
Projects
Team
Cookie policy
Privacy Policy
CONTACTS
CAAD | Corso Trieste 15/A
Novara – 28100, Italy
MINDFUL
Microvesicles: INtersection between autoimmune Diseases, Food and Unhealthy Lifestyles
Funded by MIUR (Ministry of Education, University and Research)
MINDFUL
Start date: November 2018
End date: November 2022
48 months
TYPE OF PROJECT
Investigate
Investigate how diet impacts AD development and its relation with socio-economic variables
Design cytofluorimetric panel
Design a cytofluorimetric panel to sort and deeply characterize EVs in AD patients, in order to identify biomarkers and new therapeutic targets
Investigate plant and bacteria
Investigate the role played by plant and bacteria EVs in immune modulation.
RESEARCH AREA
MINDFUL project aims to investigate the relationship between the human gut microbiota and the onset of autoimmune diseases (ADs), by evaluating the contribution of different eating habits and lifestyles in dysbiosis and unravelling the extracellular vesicles (EVs)-mediated communication mechanisms between gut bacteria and immune cells.
HOW WE ARE DOING IT
Research
Autoimmune diseases (AD) like multiple sclerosis (MS), rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), and type 1 diabetes (T1D) result from an overactive immune system and show an increasing trend, possibly linked to the prevalence of the Western diet (WD) compared to the Mediterranean diet (MD). Understanding the complex interplay between lifestyle, work history, dietary patterns, and social/family networks is crucial for promoting a ‘food for health’ approach that benefits public health and the environment.
Know-how
The project was guided by scientific “cross-cultural contamination” and “complementary expertise” principles to develop innovation and to foster innovation and technological capacity. Indeed, MINDFUL was designed with long perspectives, considering the possibility to access at synergic external technological and financial resources including grants from public and private agencies and from companies.
Since the project aims to study and understand the sociological, anthropological, environmental and biological factors influencing the development and evolution of AD, it was structured in multiple units: basic researcher unit, clinical unit, microbiome unit and industry unit.
RELATED PUBLICATIONS
- Barbero Mazzucca C, Cappellano G, Chiocchetti A.
Nutrition, immunity and aging: current scenario and future perspectives in neurodegenerative diseases. CNS Neurol Disord Drug Targets.
2023 May 2. doi: 10.2174/1871527322666230502123255.Epub ahead of print.
PMID: 37138438. - Publication of a popular science article on the scientific dissemination journal “Salute33”, edition of February 2023, entitled “Malattie autoimmune e dieta: prevenire è meglio che curare”.
- Mazzucca C.B., Scotti L., Cappellano G., Barone-Adesi F., Chiocchetti A.
Nutrition and rheumatoid arthritis onset: a prospective analysis using the UK biobank.
Nutrients. 2022 Apr 8;14(8): 1554.doi:10.3390/nu14081554 - Mazzucca CB, Raineri D, Cappellano G, Chiocchetti A.
How to Tackle the Relationship between Autoimmune Diseases and Diet: Well Begun Is Half-Done.
Nutrients. 2021;13(11):3956.doi:10.3390/nu13113956
OUR PARTNERS
- Becton Dickinson Italia S.p.a. – Milan, ITALY
- Proge Farm S.r.l – Novara, ITALY
- Istituto Auxologico Italiano – Milan area, ITALY
- Università degli Studi del Piemonte Orientale Amedeo Avogadro (UPO) – Novara, ITALY
USEFUL LINKS
Projects
Team
Cookie policy
Privacy Policy
CONTACTS
CAAD | Corso Trieste 15/A
Novara – 28100, Italy